How Much Did Profluent Bio Raise?
Funding & Key Investors

Profluent Bio, an AI-first protein design company, has secured significant capital, with its total funding reaching $141M. The company recently announced a major strategic investment of $106M, underscoring its advanced position in the competitive AI and biotechnology landscape. This latest financing round signifies a pivotal moment for Profluent Bio as it aims to accelerate its development of novel proteins for revolutionary applications in biomedicine.

What is Profluent Bio?

Profluent Bio
Business ServicesResearch & Development

Headquartered in Berkeley, CA, and founded in 2022, Profluent Bio is at the forefront of protein design, leveraging deep generative AI models. The company's core mission is to engineer and validate functional proteins that can transform the biomedical field. By developing sophisticated AI-driven platforms, Profluent Bio is poised to address complex biological challenges and unlock new therapeutic and diagnostic possibilities. The company's innovative approach places it as a key player in the burgeoning field of AI in life sciences.

How much funding has Profluent Bio raised?

Profluent Bio has raised a total of $141M across 2 funding rounds:

2024

Other Financing Round

$35M

2025

Other Financing Round

$106M

Other Financing Round (2024): $35M with participation from Insight Partners, Spark Capital, and Air Street Capital

Other Financing Round (2025): $106M led by Bezos Expeditions, Spark Capital, Altimeter Capital, and Insight Partners

Key Investors in Profluent Bio

Bezos Expeditions

Bezos Expeditions is an investment firm founded by Jeff Bezos that focuses on a diverse range of sectors including technology, healthcare, and space exploration. The firm is known for its strategic investments in innovative companies such as Airbnb, Uber, and Twitter.

Spark Capital

Spark Capital, investors in products we love by creators we admire, including Affirm, Carta, Coinbase, Cruise, Discord, Oculus, Plaid, Postmates, Slack, Twitter, and Wayfair. We know there are no playbooks or formulas for success and are here to help founders win their own way.

Altimeter Capital

Altimeter Capital is an investment firm that partners with technology companies from early growth through public markets. It manages concentrated, long term portfolios and works closely with founders and teams to support product, strategy and durable value creation.

What's next for Profluent Bio?

With substantial enterprise-level backing, Profluent Bio is strategically positioned for significant growth and expansion. The recent major strategic investment will likely fuel further research and development, enabling the company to scale its AI capabilities and broaden its protein design pipeline. This capital infusion is expected to accelerate the translation of its innovative protein designs into tangible solutions for the healthcare industry, potentially leading to new drug discoveries and advanced biotechnological tools. Profluent Bio's trajectory suggests a strong focus on market penetration and establishing leadership in AI-driven protein engineering.

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Frequently Asked Questions Regarding Profluent Bio Financial Insights

What are the most recent funding rounds that Profluent Bio has completed, and what were the funding rounds?
Profluent Bio has recently completed 2 funding rounds: Other Financing Round on Nov 19, 2025, Other Financing Round on Mar 20, 2024.
What is the total amount of funding Profluent Bio has raised to date?
Profluent Bio has raised a total of $141M in funding to date.
How many funding rounds has Profluent Bio completed?
Profluent Bio has completed 2 funding rounds.
How much funding did Profluent Bio raise in its most recent funding round?
Profluent Bio raised $106M in its most recent funding round.
Who are the lead investors in Profluent Bio's latest funding round?
The lead investor in Profluent Bio's latest funding round was Bezos Expeditions. To access investor data and explore similar companies, sign up for ZoomInfo.
Which was the largest funding round in Profluent Bio's history?
The largest funding round in Profluent Bio's history was $106M.
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